Ubiquinol (CoQ10)

Please note the following referenced scientific research is for informational use only. The results reported below may not necessarily occur in all our customers. The information should not replace advice from your health care practitioner. This information should not be read to recommend or endorse any specific product.

Coenzyme Q10 (CoQ10), also known as ubiquinone, is a fat-soluble, vitamin-like molecule naturally present in every cellular membrane within our bodies. CoQ10 is involved in cardiovascular system health through its role as an antioxidant. Ubiquinol is a metabolically active form of CoQ10 that does not require conversion by the body. This means its absorption and effectiveness is higher than regular CoQ10. As people age, the capacity of the body to produce CoQ10 declines, particularly over the age of 50 years.

Heart Health

  • CoQ10, especially in its active form (ubiquinol), is a powerful antioxidant that helps protect cells from damage caused by reactive oxygen species (ROS), which are harmful molecules that can damage cell membranes, DNA, and proteins (Zozina et al. 2018).

  • Taking CoQ10 (150 mg per day) appears to lower IL-6, an inflammatory marker, in people with coronary artery disease (CAD), demonstrating its anti-inflammatory benefits (Zozina et al. 2018).

  • Clinical evidence shows that CoQ10 supplementation with doses of 200 mg/day or higher for prolonged periods is safe, well-tolerated and significantly increases the concentration of CoQ10 in plasma, and reduces oxidative stress and mortality from cardiovascular causes (Rabanal-Ruiz et al. 2021).

  • CoQ10 supplementation improves heart failure symptomatology and clinical outcome in patients undergoing coronary artery bypass graft surgery by enhancing mitochondrial respiration and increasing myocardial tolerance to oxidative stress (Rabanal-Ruiz et al. 2021).

Energy

  • Ubiquinol, the active antioxidant form of CoQ10, supports energy production by playing a crucial role in the mitochondrial electron transport chain, which generates ATP—the main energy molecule for cells.

  • Ubiquinol improves mitochondrial function, egg and embryo quality, and may reduce miscarriage risk, particularly in Assisted Reproductive Technology (ART) in older women.

References

  • Zozina VI, Covantev S, Goroshko OA, Krasnykh LM, Kukes VG. 2018. "Coenzyme Q10 in Cardiovascular and Metabolic Diseases: Current State of the Problem." Curr Cardiol Rev. ;14(3):164-174. doi:10.2174/1573403X14666180416115428

  • Rabanal-Ruiz, Y., Llanos-González, E., & Alcain, F. J. 2021. "The Use of Coenzyme Q10 in Cardiovascular Diseases." Antioxidants (Basel, Switzerland), 10(5), 755. https://doi.org/10.3390/antiox10050755

  • David R. Meldrum, Robert F. Casper, Antonio Diez-Juan, Carlos Simon, Alice D. Domar, Rene Frydman. 2016. "Aging and the environment affect gamete and embryo potential: can we intervene?", Fertility and Sterility, Volume 105, Issue 3, Pages 548-559, ISSN 0015-0282, https://doi.org/10.1016/j.fertnstert.2016.01.013.